Get Nebula using my link for 40% off an annual subscription: https://go.nebula.tv/medlifecrisis Watch this video ad-free: https://nebula.tv/videos/medlifecrisis-how-to-prevent-almost-all-disease Watch my conversation with another amazing guest where we discuss the effects and medical uses of recreational drugs https://nebula.tv/videos/medlife-crisis-the-worst-censorship-of-research-in-history-psychedelic-science-policy-with-prof-david-nutt It's the best way to support this channel. Thank you! Nebula creators get a percentage of the subscription fees from anyone who signs up using their links. Want to support your favourite creator? Share links to their Nebula channel or videos. You can also check out Real Science's brilliant Nebula Original series 'Becoming Human' https://nebula.tv/becominghuman This is an in-depth interview with scientist, author and expert on longevity science, Dr Andrew Steele. We discuss what ageing even is, whether it should be regarded as a disease, how we differ from other animals, where the research is, what treatments look promising, health and economic policy, and what the future looks like. Watch Andrew and I chat about all things wearable - what numbers you should care about, which you shouldn’t https://www.youtube.com/watch?v=9H40yatCwo0 Find more Andrew here: null Book: https://ageless.link/ https://twitter.com/statto https://www.instagram.com/andrewjsteele If you do want to listen to this as a podcast, it is available here (I hope!) https://open.acast.com/public/streams/63d64aa1452847001186943f/episodes/63e10209436c360011deab42.mp3 How to prevent almost ALL disease https://shows.acast.com/medlifecrisis/episodes/how-to-prevent-almost-all-disease via @acast Sign up for my free newsletter: https://medlife.substack.com/ Watch exclusive, ad-free content from me and hundreds of other creators only on Nebula: https://watchnebula.com/medlifecrisis I’ll add chapters as soon as I get home! Edit: many thanks to user Dihydrousoxide for making them, which I'm shamelessly stealing! 0:00 Intro 5:37 Why you got into the anti-ageing field? 7:15 Ageing as a cause of death 9:18 What is ageing? 13:32 Hallmarks of Ageing - Senescent Cells 17:25 How do we target senescent cells? 20:10 What are telomeres? 22:40 How do we stop telomeres shortening? 26:00 Evolution optimised for reproduction, not ageing well - BOFFFs 33:54 Autophagy - cellular recycling 42:00 Testing of rapamycin - Effective Dose 45:35 Why don't we have human data on rapamycin? 46:24 Metformin - TAME trial monetary issues 49:04 What is Metformin? 52:50 How does Metformin work as an anti-ageing drug? 54:03 What therapies excite you at the moment? 58:39 Thoughts on Calorie restriction 1:04:53 Rhesus Monkey Diet Trials 1:08:14 Potential Therapies - theoretical mechanistic science 1:12:46 Amyloid Studies 1:17:20 Should we stop ageing? 1:31:29 Where do you see the anti-ageing field being in 2050? 1:43:03 Outro ----------------- More Medlife Crisis: https://twitter.com/medcrisis null https://www.youtube.com/channel/UCXFgI0Lgrwc_fY2ttqQ9Yhg https://watchnebula.com/medlifecrisis https://www.instagram.com/medcrisis