There’s one particular mental trap that seems to fool everyone, especially those WITH medical knowledge. THANK YOU for your support in 2022. This Christmas I'm donating my sponsorship fee to charity via GiveWell because I know it'll help those in need. If you can join me in giving something, please do – anything helps. Have a wonderful festive season! www.givewell.org/medlife Sign up for my free newsletter: https://medlife.substack.com/ Watch this video free of ads at Nebula: https://nebula.tv/videos/medlifecrisis-why-people-keep-falling-for-things-that-dont-work My video on vaccines and people’s reactions: https://www.youtube.com/watch?v=5iABaxRWGxk My video on bias, which mentions other failed therapies (two parter): https://www.youtube.com/watch?v=ooWA4tM_gUs Kevin Klatt’s post https://www.instagram.com/p/Cb72YXVLCf3/ Andrew Steele’s dissection of ‘Blueprint’ longevity plan https://www.youtube.com/watch?v=7rs_JK-pTTQ Writing: Rohin Francis Editing: Tanmay Nandanikar and Rohin Francis Thumbnail design: Simon Buckmaster 0:00 Intro 3:41 The demarcation problem 6:44 Pseudoscience 9:06 Homeopathy and chiropractic 11:20 It's nice to feel nice 13:37 Bioplausibility 16:39 The mechanistic bias 17:06 Hard vs soft; clean vs messy science 20:25 Mechanistic examples: COVID Rx and masks 24:40 Diets 28:12 Vitamin D supplements 36:36 The Big Pharma graveyard 45:33 Most therapies don't work 47:07 Influencers' love of sexy mechanisms 50:25 Closing summary References: Convalescent plasma doesn’t work https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)00897-7/fulltext Meta-research: A comprehensive review of randomized clinical trials in three medical journals reveals 396 medical reversals https://elifesciences.org/articles/45183 Most healthcare interventions don’t work https://www.jclinepi.com/article/S0895-4356(22)00100-7/fulltext COVID experts give Thanksgiving tips https://www.statnews.com/2022/11/21/how-infectious-disease-experts-are-responding-to-covid-nearly-three-years-in/ VITAL study (vitamin D) https://www.nejm.org/doi/full/10.1056/NEJMoa2202106?query=featured_home https://www.nejm.org/doi/full/10.1056/NEJMe2205993 VITAL website https://www.vitalstudy.org/index.html Vitamin D in kids https://jamanetwork.com/journals/jamapediatrics/article-abstract/2798998 MAST pants don’t work https://pubmed.ncbi.nlm.nih.gov/10796828/ Nesiritide https://www.ahajournals.org/doi/10.1161/CIRCHEARTFAILURE.118.005440 REDOX https://www.nejm.org/doi/10.1056/NEJMoa1212722 PANTHER IPF https://www.nejm.org/doi/10.1056/NEJMoa1212722 OSCILLATE https://www.nejm.org/doi/10.1056/NEJMoa1215554 ----------------- More Medlife Crisis: https://twitter.com/medcrisis https://www.youtube.com/channel/UCXFgI0Lgrwc_fY2ttqQ9Yhg https://watchnebula.com/medlifecrisis https://www.instagram.com/medcrisis https://www.facebook.com/Medlifecrisis