For years, the best treatment for serious cases of #eczema ’s itchy, red inflammation was drugs with dangerous side effects. Now half a dozen novel treatments are available that largely evade those effects, Sarah Zhang reports—even as their price tag still keeps them out of reach for some patients: https://theatln.tc/10nEOOA5 Eczema is estimated to affect 10 percent of Americans. Of those, a large minority suffer from moderate to severe eczema that seeps into everyday life. In the past, if over-the-counter treatments failed, doctors resorted to more powerful oral steroids, which can calm eczema but make you more prone to infections and other conditions. Newer drugs have less collateral damage—some intercept the immune-signaling molecules that trigger itch and skin inflammation, and some scramble the signal after cells have received it. “The development of these drugs came after years of research zeroed in on some of the key immune molecules dysregulated in eczema,” Zhang writes. “But serendipity played a role too: The first such drugs were originally developed for other conditions, such as rheumatoid arthritis—only to be repurposed when researchers realized that they targeted the very pathways involved in eczema. The breakthroughs in eczema treatment, in fact, are part of a broader revolution in treating inflammatory disorders; both classes of new drugs are now used to tune the immune system in a whole host of different conditions.” But getting patients these newer drugs can mean a lot of time fighting with insurance, Zhang continues. “At the moment, steroids are also cheap and easily available. They’re not going anywhere as long as the new treatments still come with hefty price tags.” Read more: https://theatln.tc/10nEOOA5 #health #medicine 🎨: The Atlantic. Source: Getty.
Show more