Is Lyme disease really that difficult to diagnose? And why is that? With more than 3 million tests performed annually in the US alone, every physician should at least roughly understand what these tests mean and, more importantly, what they don't. There are many misconceptions and tons of misinformation regarding Lyme disease. I hope this video helps dispel at least some of them. Every clinician has to be able to recognize life-threatening infections like sepsis and CNS infections right away! This free online course teaches you just that! If you work with patients, don't put this off! You will need what you learn in this course the very next shift! A Clinical Approach to Serious Infections in Adults: What Every Physician Should Know: https://drviktorkotarski.podia.com/recognize-serious-infections-early DISCLAIMER: Please always keep in mind that my videos are intended for educational purposes only. The content of my videos is NOT medical advice. I do not practice medicine over the Internet. If you are a patient and have any questions about your health, please talk to your doctor. CHAPTERS: 00:00 Why do we test for Lyme disease so much? 01:29 Why high specificity isn't enough 03:13 Do positive antibodies for B.burgdorferi definitely confirm Lyme disease? 04:00 Why a misinterpreted positive test is dangerous 05:27 How can we get better at diagnosing Lyme disease? REFERENCES & RECOMMENDED READING: 1. Kalmár Z, Briciu V, Coroian M, Flonta M, Rădulescu AL, Topan A, et al. Seroprevalence of antibodies against Borrelia burgdorferi sensu lato in healthy blood donors in Romania: an update. Parasit Vectors. 2021 Dec 4;14(1):596. 2. Burn L, Pilz A, Vyse A, Gutiérrez Rabá AV, Angulo FJ, Tran TMP, et al. Seroprevalence of Lyme Borreliosis in Europe: Results from a Systematic Literature Review (2005–2020). Vector Borne Zoonotic Dis. 2023 Apr 1;23(4):195–220. 3. Lantos PM, Branda JA, Boggan JC, Chudgar SM, Wilson EA, Ruffin F, et al. Poor Positive Predictive Value of Lyme Disease Serologic Testing in an Area of Low Disease Incidence. Clin Infect Dis. 2015 Nov 1;61(9):1374–80. 4. Eldin C, Raffetin A, Bouiller K, Hansmann Y, Roblot F, Raoult D, et al. Review of European and American guidelines for the diagnosis of Lyme borreliosis. Med Mal Infect. 2019 Mar;49(2):121–32. 5. Halperin JJ, Baker P, Wormser GP. Common misconceptions about Lyme disease. Am J Med. 2013 Mar;126(3):264.e1-7.