A sensuous song of molecular machines. Support A Capella Science: http://patreon.com/acapellascience Subscribe! null Follow Dorothy Andrusiak: https://www.facebook.com/dorothyandrusiak MP3: https://timblais.bandcamp.com/track/nanobot ---------------- A CAPELLA SCIENCE STUFF: Patreon: http://patreon.com/acapellascience Facebook: http://facebook.com/acapellascience Twitter: http://twitter.com/acapellascience Instagram: http://instagram.com/acapellascience Bohemian Gravity poster: https://store.dftba.com/products/bohemian-gravity-poster Follow me @acapellascience on Twitter, Instagram, Snapchat! ---------------- DOROTHY ANDRUSIAK STUFF: Facebook: http://facebook.com/dorothyandrusiak Instagram: https://instagram.com/andrusiak.1/ ---------------- ERC LINKS: European Research Council MolFactory Advanced Grant: https://erc.europa.eu/projects-figures/erc-funded-projects/results?search_api_views_fulltext=Molfactory Prof Dave Leigh group webpage: http://www.catenane.net/ EPRSC LINKS: EPSRC Molecular Robotics program: http://gow.epsrc.ac.uk/NGBOViewGrant.aspx?GrantRef=EP/P027067/1 ---------------- REFERENCES: [1] http://www.catenane.net/pdfs/articles/2010walker_naturechem.pdf [2] https://pubs.acs.org/doi/pdf/10.1021/ja058303m [3] https://www.nature.com/articles/nature05452 [4] https://pubs.acs.org/doi/pdf/10.1021/ja904104c [5] https://pubs.acs.org/doi/pdf/10.1021/ol102422h [6] http://pubs.rsc.org/en/content/articlehtml/2016/cc/c6cc08586e [7] https://www.nature.com/articles/nature23677 [8] http://pubs.rsc.org/en/Content/ArticleLanding/1994/C3/C39940001213#!divAbstract [9] https://pubs.acs.org/doi/pdf/10.1021/ol0487985 [10] https://pubs.acs.org/doi/pdf/10.1021/ja9712229 [11] http://rotaxane.net/pdfs/articles/Leigh%20Sequential%20Peptide%20Synthesis%20Science%202013.pdf [12] https://pubs.acs.org/doi/pdf/10.1021/ja908524x [13] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5504628/ [14] https://www.youtube.com/watch?v=b_cp8MsnZFA [15] https://www.wehi.edu.au/wehi-tv/chromosome-and-kinetochore [16] https://www.wehi.edu.au/wehi-tv/x-inactivation-and-epigenetics [17] https://www.wehi.edu.au/wehi-tv/molecular-visualisations-dna [18] ‘Inner Life of the Cell,’ © 2006 President and Fellows of Harvard College. Created by Alain Viel, PhD and Robert Lue, PhD in collaboration with XVIVO, LLC and John Liebler, Lead Animator. Made possible through the generous support of the Howard Hughes Medical Institution's Undergraduate Science Education Program. ---------------- NANOBOT (Music: 'Havana' by Camila Cabello) To plan a nanobot Map out the molecules to span the nanobot Add on the motors used to man the nanobot Signals to talk with a commander Software and logic's grammar Programmed in nanobot Beginning you better control the movement (The thermal storm abrew) Room temperature systems are always moving (Your system's moving too) The pieces and links you pick will limit (The states it can assume) As is it'll randomly shuffle through them Now force it with the right Fuel Ordered and energetic A bias in the setup Adding entropy through A cycle that'll let it Put work to load Oh na na nanobot So plan your nanobot With steps whose opposite'll jam the nanobot Barriers free energy expenditure will drop To let it pass and then to catch it Go through the door and latch it A ratchet nanobot Let's see You've animated these lil' gadgets? Damn! Next let's see you handle informatics fam (Nano-informatics) 1-0 the structure of a cache or RAM Switches are the way to data save and plan (flip it on) Flip it chemically Photochemically Or electrically Add a flippable knee (then what?) Make a little more deep The decisional tree (data) If you need a calculator how be Logic gates, like "a, not b" Input's a cation, as key (that's key) And you get a photon as a reading So plan your nanobot To be in part an info scanner nanobot Reading and writing coded data that allot Freedom to do as you program it A Turing automatic Full gamut nanobot Doesn't that look life-like? (x3) (Break me down I am) A metananobot The muse and model of synthetic nanobots Working in concert as a replicable lot For all I try to be more than it Though sentient and organic I am a nanobot