On July 19, 2016, the ACT-AD Coalition hosted this webinar on clinical meaningfulness in Alzheimer’s disease. The webinar highlighted the history of co-primary outcomes for measuring clinical meaningfulness in overt dementia; explored how thinking on co-primary endpoints is evolving as treatment moves earlier in the disease course; and examined if policy recommendations are necessary for future success in the Alzheimer’s disease clinical trials. For more information about ACT-AD, visit act-ad.org.