(0:00) Sequoia Capital’s Roelof Botha joins Jason (3:35) The state of the Silicon Valley ecosystem (8:00) Supergut - Get 30% off with code TWIST at https://supergut.com/ (9:31) “Crucible Moments” and their significance (14:31) Pre-IPO vs. Post-IPO market values (18:10) Founder ambition and mistakes made during “Crucible Moments” (22:25) The importance of founders starting narrow and what makes a great VC in tech (27:20) Coda - Get a $1,000 startup credit at https://coda.io/twist (28:49) Commonalities between the AI boom and the crypto boom (33:31) U.S. frameworks regarding crypto (37:10) Mercury - Join 100K+ startups banking with Mercury at http://mercury.com/ (38:23) The milestone-based reward system in venture capital (43:24) Taking over as head steward at Sequoia Capital (56:02) “Crucible Moments” at Sequoia (1:05:57) Maintaining consistency in life and venture Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp FOLLOW Roelof: https://twitter.com/roelofbotha FOLLOW Jason: https://linktr.ee/calacanis Thanks to our partners: (8:00) Supergut - Get 30% off with code TWIST at https://supergut.com/ (27:20) Coda - Get a $1,000 startup credit at https://coda.io/twist (37:10) Mercury - Join 100K+ startups banking with Mercury at http://mercury.com/ Listen here: Apple: https://podcasts.apple.com/us/podcast/this-week-in-startups-audio/id315114957 Spotify: https://open.spotify.com/show/6ULQ0ewYf5zmsDgBchlkr9 Overcast: https://overcast.fm/itunes315114957/this-week-in-startups-audio More from us: Twitter: https://twitter.com/twistartups Instagram: https://www.instagram.com/thisweekinstartups Official site: https://thisweekinstartups.com/ Subscribe to our YouTube to watch all full episodes: https://www.youtube.com/channel/UCkkhmBWfS7pILYIk0izkc3A Subscribe to TWiST Clips for all the best moments: https://www.youtube.com/channel/UCS7tJlcUA6PzVHEMo-X7ddg #startups #entrepreneurship #investing #angelinvesting #tech #news #business