Serotonin is an extremely powerful molecule, and it's the target for many therapeutic and recreational drugs. Understanding serotonin's story -- how it's made, stored, released, how it activates a postsynaptic cell, how it is removed from the synapse and how it is reused and recycled -- will help you to understand many of the pharmacological manipulations we have for this amazing monoamine. Ready to get happy? Let's unpack serotonin together. #physiology #nursingstudent #neurotransmitters #serotonin #psychedelic #antidepressant CORRECTION *In the structure of MDMA shown in the video, there is a methyl missing alpha with respect to the nitrogen, but it's not part of the pharmacophore.* Disclaimer Penguin Prof videos are produced for informational and educational purposes only, and they not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider with any questions you may have regarding a medical condition. Chapters: Intro: 0:00 The brain on serotonin: 0:20 Neuron review: 1:09 Six steps of the serotonin story: 1:30 Step 1: Synthesis: 2:05 Step 2: Storage: 2:26 Step 3: Release: 2:39 Step 4: Postsynaptic cell activation: 2:42 Step 5: Clearing: 3:19 Step 6: Reuse and breakdown: 3:58 Intro to pharmacological manipulation (how the drugs work): 4:31 MAOIs: 5:20 Marplan, Nardil, Ensam, Parnate Serotonin reuptake inhibitors: 5:41 SSRIs vs. SNRIs: 6:00 SSRIs: Celexa, Lexapro, Prozac, Luvox, Paxil, Zoloft, Priligy SNRIs: Khedezla, Pristiq, Cymbalta, Drizalma, Irenka, Fetzima, Savella, Effexor Serotonin agonists: LSD and psilocybin (magic mushrooms): 6:49 More magic - pharmacophores: 7:08 Ecstasy (MDMA): 7:34 Self-quiz: 8:28 Review: 8:36 Outro: 9:04 Penguin Proff Staff: Organic chemistry consultant in residence: FabioChem (Fabio Agnelli, Ph.D) Happiness Coordinator: Flops the Penguin Content Creator, Producer, Editor and Narrator: The Penguin Prof (Valerie Pennington) Want more Penguin Prof? Subscribe: null FB Page: https://www.facebook.com/ThePenguinProf Instagram: https://www.instagram.com/penguinprof/ TikTok: https://www.tiktok.com/@penguinprof Twitter: https://twitter.com/penguinprof Web: http://www.penguinprof.com/ LinkedIn: https://www.linkedin.com/in/penguinprof Videos Mentioned: The Action Potential: https://www.youtube.com/watch?v=mDKlzNn9f_g Know Your Neurons: https://www.youtube.com/watch?v=WLED5WsvCGI Basic Signal Transduction: Ligands and Receptors: https://www.youtube.com/watch?v=pH_ibPHK0y0 Popular Videos: Equilibrium Potentials and Driving Force: https://www.youtube.com/watch?v=Kdnj0o1Wxqg Take Great Notes: https://www.youtube.com/watch?v=pYRmNql_12s Should You Use Your Textbook? https://www.youtube.com/watch?v=9m50QeXtpBM Enzyme Regulation Explained: https://www.youtube.com/watch?v=b2Ebt2nU6iM Homeostasis and Feedback: https://www.youtube.com/watch?v=mn-2ob0F5e8 Redox Relief: https://www.youtube.com/watch?v=eL0BH5O9Sdo Levels the Protein Structure: https://www.youtube.com/watch?v=OwkKw53dBtQ How Hormones Work: https://www.youtube.com/watch?v=KnIu7DDflw8 Chemistry Basics Part I: https://www.youtube.com/watch?v=MYuh5yErdfA Chemistry Basics Part II: https://www.youtube.com/watch?v=Juw7HBg0zZs Understanding Chemical Structures: https://www.youtube.com/watch?v=FbaXQ8u6IP8 Blood Types: ABO and Rh: https://www.youtube.com/watch?v=L06TJTMVkBo All Rights Reserved © 2023, The Penguin Prof Affiliate Links Below you'll find a list of products or services that I truly believe in, support and pay for. If you click them, a small amount of change goes to support this channel. Rocketbook: Use and re-use paper, scan and digitize everything and send your stuff wherever you need it: [[https://bit.ly/3wv9ZkJ](https://bit.ly/3wv9ZkJ)] Penguin Prof is Supported by Audible! I've been an Audible addict since 2013. Audible is the premier provider of digital audiobooks. Audible has over 150,000 titles to choose from in every genre. Audible titles play on iPhone, Kindle, Android and more than 500 devices for listening anytime, anywhere. Click to learn more and download a FREE audiobook of your choice! http://www.audibletrial.com/PenguinProf Discounts for Camtasia (my favorite video editor) and Snagit (my favorite screen annotation software): https://techsmith.z6rjha.net/5bDN1o Descript: Simply the EASIEST and FASTEST way to produce transcripts and captions for your videos: https://www.descript.com/?lmref=diMR8w Royalty-Free Music by Epidemic Sound If you're looking for an amazing library of royalty-free music, as well as over 60,000 sound effects, look no further than Epidemic Sound. I've been a member for years and I love being able to find the perfect track for every project. Help support my channel if you're interested and sign up with this link: https://www.epidemicsound.com/referral/xgv85e/ GEAR: Mic: Apogee HypeMic Computer: Apple Mac mini (M1, 2020) SOFTWARE: Camtasia Descript (for subtitles and transcripts)